A Market Space Beyond Lucentis and Eylea for Retinal Vein Occlusion Treatment

 


What is Retinal Vein Occlusion?

The most prevalent cause of vision loss in older people and the second most common retinal vascular disorder to endanger one's ability to see is retinal vein occlusion. Our calculations indicate that there were over 1.2 million diagnosed cases of Retinal Vein Occlusion in the 7MM in 2021, which is projected to rise by 2032. Additionally, in the 7MM, girls outnumbered males in the overall number of diagnosed prevalent cases of Retinal Vein Occlusion (RVO) in the year 2021. By the year 2032, these cases are anticipated to rise, according to estimations. Additionally, it was noted that BRVO cases outnumbered CRVO cases in total diagnosed frequent RVO cases in the US in 2021, and these instances are projected to rise sharply by 2032.


Age and systemic vascular problems are major risk factors for RVO, and age is a significant factor in determining the severity of the disease's progression. As a result, the prevalence and awareness of the condition are rising along with the growing elderly population. It typically affects people in their sexagenarian years and older, making diagnosis and treatment challenging because of the related comorbidities, including diabetes and high blood pressure.



However, the retinal vein occlusion treatment setting remains just as constrained as it was ten years ago. A curative treatment that reverses retinal vascular occlusion is a critical unmet need, even though there are FDA-approved medications for the indication. The treatments for retinal vein occlusion that are currently available manage the symptom to stop additional vision loss and lessen the harm caused by side effects such as macular edoema, ischemia, or neovascularization.


Currently, the FDA has approved three medications: Roche's Lucentis (ranibizumab), Eylea (aflibercept) by Regeneron, which are intravitreal injections of anti-VEGFs, and Ozurdex by AbbVie, which is a dexamethasone implant, to treat macular edoema secondary to branch retinal vein occlusion and central retinal vein occlusion market. Off-label treatments for retinal vein occlusion, such as Roche's Avastin (bevacizumab) and intravitreal triamcinolone, are popular and widely utilized.


As the only approved medication in the distinct corticosteroid market with no substantial competitors, Ozurdex injection by AbbVie, a dexamethasone implant with a distinctive mechanism of action, has earned a significant position in the competitive retinal vein occlusion therapy market. This second-line therapy for eyes with persistent edoema that do not respond well to anti-VEGF injections has a patent exclusivity period until 2023, so there is little to worry about. Off-label intravitreal triamcinolone, however, enters this restricted area with less impact.


Along with these rising stars, there are a few early-stage retinal vein occlusion medications worth mentioning, such as ANXV by Annexin Pharmaceuticals, Autologous Bone Marrow CD34+ Stem Cells by The Emmes Company, and EYP-1901 (vorolanib) by EyePoint Pharmaceuticals. If approved, these medications may offer the much-needed RVO cure. It is still too soon to get overly excited about these medications, but based on our data, they are the ones to keep an eye on in a retinal vein occlusion treatment market that is now dominated by anti-VEGF and corticosteroids.

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